Antiaging and Longevity
Living longer and healthier.
No one wants to live longer but in a debilitated state. Research peptides continue to captivate us due to their potential to enhance longevity and mitigate the effects of aging.
Epitalon
Epitalon is notable for its impact on telomere elongation and circadian rhythm regulation, which are vital for cellular rejuvenation and aging processes. Epitalon's potential to activate telomerase and extend telomeres can lead to significant anti-aging effects, with implications for increased lifespan and reduced age-related diseases.
GHK-Cu
GHK-Cu enhances skin repair and systemic healing by promoting collagen and elastin production, angiogenesis, and anti-inflammatory responses. Its broad regenerative properties make it a powerful candidate for therapeutic use in tissue engineering and regenerative medicine.
BPC-157
BPC-157 known for its quick and robust healing effects, particularly in the gastrointestinal tract and inflamed tissues, demonstrates significant potential in clinical settings for tissue repair and regeneration, showcasing its utility beyond mere symptom management.
Semax
Semax is primarily leveraged for its neuroprotective and cognitive-enhancing effects. It stimulates neuronal survival and brain-derived neurotrophic factor (BDNF) production, which are crucial for maintaining cognitive function as one ages.
TB-500
TB-500supports healing by modulating actin, a cell-structuring protein, enhancing recovery from muscular injuries and other tissue damages, which is essential for maintaining long-term physical health.
NAD+
NAD+ is essential for metabolic functions such as DNA repair and sirtuin activity, both critical in aging. Supplementing NAD+ can improve mitochondrial function and has been linked with reversing aspects of aging and improving neuroprotective functions.
Thymosin Alpha-1
Thymosin Alpha-1, another powerful peptide, enhances immune system function. It has been used to treat chronic diseases and infections, which could indirectly contribute to longevity by maintaining a robust immune response.
Notable References:
Epitalon
- Anisimov, V. N., et al. "The synthetic pineal peptide epitalon restores disturbed neuroendocrine regulation in senescent monkeys." Neuroendocrinology Letters 21.4 (2000): 251-258.
- Khavinson, Vkh, et al. "Peptides of pineal gland and thymus prolong human life." Neuroendocrinology Letters 24.3-4 (2003): 233-240.
GHK-Cu
- Pickart, L., et al. "The human tri-peptide GHK and tissue remodeling." Journal of Biomaterials Science, Polymer Edition 19.8 (2008): 969-988.
- Maquart, F. X., et al. "Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+." FEBS Letters 238.2 (1988): 343-346.
BPC-157
- Sikiric, P., et al. "The beneficial effect of BPC 157, a 15 amino acid peptide, on gastrointestinal and brain lesions and function in rats." Digestive Diseases and Sciences 44.6 (1999): 1157-1163.
- Chang, C. H., et al. "BPC 157 enhances the growth hormone receptor expression in tendon fibroblasts." Molecules 19.11 (2014): 19066-19077.
Semax
- Dolotov, O. V., et al. "Semax, an analog of ACTH (4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus." Brain Research 1117.1 (2006): 54-60.
- Eremin, K. O., et al. "Neuroprotective and nootropic drug noopept rescues α-synuclein amyloid cytotoxicity." Journal of Molecular Biology 404.5 (2010): 650-656.
TB-500 (Thymosin Beta-4)
- Goldstein, A. L., et al. "Thymosin β4: A multi-functional regenerative peptide. Basic properties and clinical applications." Expert Opinion on Biological Therapy 12.1 (2012): 37-51.
NAD+
- Braidy, N., et al. "Role of nicotinamide adenine dinucleotide and related precursors as therapeutic targets for age-related degenerative diseases: Rationale, biochemistry, pharmacokinetics, and outcomes." Antioxidants & Redox Signaling 30.2 (2019): 251-294.
Thymosin Alpha-1
- Garaci, E., et al. "Thymosin alpha1 and cancer: action on immune effector and tumor target cells." Annals of the New York Academy of Sciences 1269.1 (2012): 26-33.
